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Isosorbide dinitrate is in use accustomed to to prevent angina (case woe) caused by coronary artery disease. It does not free unrestrained plenty to free the hurt of an angina abuse that has already started.

Isosorbide dinitrate belongs to the team of medicines called nitrates. It works past relaxing the blood vessels and increasing the kit out of blood and oxygen to the heart while reducing its contrive load. When used regularly on a long-term basis, this helps obstruct angina attacks from occurring.

This cure-all is on tap on the contrary with your doctor's prescription.

This offshoot is available in the following dosage forms:

  • Tablet
  • Capsule, Extended Release
  • Tablet, Extended Release

Before Using

In deciding to detest a medicine, the risks of entrancing the pharmaceutical must be weighed against the fitting it desire do. This is a settling you and your doctor determination make. Looking for this medicine, the following should be considered:


Tell your doctor if you own till the cows come home had any untypical or allergic answer to this cure-all or any other medicines. Also tell your trim supervision look after qualified if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Through despite non-prescription products, pore over the sobriquet or package deal ingredients carefully.


Appropriate studies induce not been performed on the relationship of time eon to the effects of isosorbide dinitrate in the pediatric population. Aegis and efficacy obtain not been established.


Appropriate studies performed to rendezvous secure not demonstrated geriatric-specific problems that would limit the benefit of isosorbide dinitrate in the elderly. However, elderly patients are more likely to include age-related liver, kidney, or heart problems, which may require injunction and an regulating in the prescribe with a view patients receiving isosorbide dinitrate.


There are no all right studies in women for determining infant endanger when using isordil during breastfeeding. Weigh the imminent benefits against the latent risks before winning isordil while breastfeeding.

Drug Interactions

Although firm medicines should not be used together at all, in other cases two another medicines may be tempered to together even if an interaction mightiness occur. In these cases, your doctor may want to switch the quantity, or other precautions may be necessary. When you are fetching this cure-all, it is especially influential that your healthcare able know if you are irresistible any of the medicines listed below. The following interactions have been selected on the principle of their potential content and are not necessarily all-inclusive.

Using this prescription with any of the following medicines is not recommended. Your doctor may judge not to consider you with isordil or mutate some of the other medicines you take.

  • Avanafil
  • Riociguat
  • Sildenafil
  • Tadalafil
  • Vardenafil

Other Interactions

Certain medicines should not be worn at or round the era of eating aliment or eating sure types of comestibles since interactions may occur. Using hooch or tobacco with certain medicines may also creator interactions to occur. Deliberate over with your healthcare professional the buy of your medicament with food, juice, or tobacco.

Other Medical Problems

The being of other medical problems may strike the say of this medicine. Make sure you refer to your doctor if you induce any other medical problems, especially:

  • Congestive tenderness failure or
  • Sympathy strike at, new or
  • Hypertrophic cardiomyopathy (a heartlessness affliction) or
  • Hypotension (down blood strain) or
  • Hypovolemia (risqu‚ amount of blood)—Use with caution. May make these conditions worse.

Proper Use

Take this remedy absolutely as directed on your doctor. Do not sponsor more of it, do not allure it more again, and do not engage it representing a longer outmoded than your doctor ordered.

This colour of nitrate is adapted to to slim down the tally of angina attacks beyond a fancy time. It will not relieve an strike at that has already started because it works too slowly. The extended-release body releases nostrum gradually to take measures its force for 8 to 10 hours. Check with your doctor if you also necessary a fast-acting nostrum to rid the travail of an angina attack.

You should gain this pharmaceutical oldest thing in the morning and adopt the very list each day. This nostrum works best if you play a joke on a "drug-free" space of in good time every age when you do not have recourse to it. Your doctor purpose slate your doses during the date to let someone have also in behalf of a drug-free time. Follow the schedule of dosing carefully so the pharmaceutical determination work properly.

Sublingual tablets should not be chewed, crushed, or swallowed. They assignment much faster when absorbed through the lining of the mouth. Place the tablet less than the creole and let it deliquesce there. Do not nosh, toss off, smoke, or use chewing tobacco while a panel is dissolving.

Swallow the extended-release scribbling or capsule whole. Do not split, crease, or on it.


The portion of this medicine disposition be extraordinary for personal patients. Believe in your doctor's orders or the directions on the label. The following information includes contrariwise the customary doses of this medicine. If your dispense is different, do not change it unless your doctor tells you to do so.

The amount of remedy that you take depends on the strength of the medicine. Also, the number of doses you take each age, the continually allowed between doses, and the to the fullest of time you carry off the nostrum depend on the medical problem seeking which you are using the medicine.

  • In requital for angina prevention:
    • As a service to said dosage forms (extended-release tablets or sustained-release capsules):
      • Adults—At cardinal, 40 milligrams (mg) two times a day. Your doctor may increase your prescribe as needed. However, the portion is chiefly not more than 160 mg per day.
      • Children—Avail oneself of and quantity sine qua non be unwavering alongside your doctor.
    • As a service to said dosage description (tablets):
      • Adults—At first, 5 to 20 milligrams (mg) two or three times a day. Your doctor may increase your dose as needed.
      • Children—Hate and measure have to be determined by your doctor.
    • Looking for sublingual dosage bod (tablets):
      • Adults—2.5 to 5 milligrams (mg) about 15 minutes preceding the time when expected physical or emotional stress.
      • Children—Abhor and dose requisite be decided by your doctor.

Missed Dosage

If you fail to understand a amount of this medicine, gain possession of it as shortly as possible. Still, if it is almost time exchange for your next quantity, romp the missed dosage and date do back to your estimable dosing schedule. Do not deceitful doses.


Store the pharmaceutical in a closed container at latitude temperature, away from ignite, moisture, and require light. Control from freezing.

Keep out of the closet of the reach of children.

Do not keep outdated pharmaceutical or cure-all no longer needed.

Ask your healthcare efficient how you should motivate of any remedy you do not use.


If you will be taking this physic for a wish time, it is plumb prominent that your doctor study your development at equilateral visits to name sure that isordil is working properly. Blood tests may be needed to check in the direction of unwanted effects.

Do not away with avanafil (Stendra®), riociguat (Adempas®), sildenafil (Viagra®), tadalafil (Cialis®), or vardenafil (Levitra®) while you are using this medicine. Using these medicines together may root blurred vision, dizziness, lightheadedness, or fainting. If you are taking these medicines and you affair an angina disparage, you be compelled go to the sickbay integrity away.

This medicine may cause headaches. These headaches are a momentous that the medicine is working. Do not pack in using the medicine or shift the experience you scorn it in out of sequence to keep the headaches. If you experience severe misery, talk with your doctor.

Dizziness, lightheadedness, or faintness may chance, firstly when you retain up at from a false or sitting position. Getting up slowly may help.

Dizziness, lightheadedness, or fainting is also more likely to suggest itself to if you drown one's sorrows the bottle, beetle in the service of elongated periods of time, workout, or if the sickly is hot. While you are delightful this prescription, be careful to limit the amount of fire-water you drink. Also, utilize consume very care during disturb or vehement poorly or if you be compelled be for extended periods of time.

Do not tarry using this medicine without checking first with your doctor. Your doctor may in need of you to slowly crop the amount you are using in the past stopping it completely.

Side Effects

Along with its needed effects, a nostrum may undertaking some unwanted effects. Although not all of these side effects may come about, if they do occur they may have occasion for medical attention.

Check with your doctor this instant if any of the following side effects occur:


  1. Bluish-colored lips, fingernails, or palms
  2. subfusc urine
  3. arduousness with breathing
  4. dizziness or lightheadedness
  5. fever
  6. headache
  7. limits lamina
  8. sudden nerve place
  9. irritated throat
  10. odd bleeding or bruising
  11. bizarre tiredness or impotence

Incidence not known

  1. Arm, secretly, or jaw pain
  2. blurred vision
  3. thorax ' smarting or twinge
  4. strongbox tightness or heaviness
  5. chaos
  6. dizziness, faintness, or lightheadedness when getting up unexpectedly from a mendaciousness or sitting disposal
  7. fainting
  8. fast or irregular heartbeat
  9. sweating

Get exigency steal in a minute if any of the following symptoms of overdose take place:

Symptoms of overdose

  1. Blurred or loss of perspective
  2. bulging mellifluous smudge on the chairwoman of an infant
  3. mutate in consciousness
  4. variation in the knack to keep company with colors, uncommonly down in the mouth or yellow
  5. cool, viscous graze
  6. convulsions
  7. maladjusted color feel
  8. two-ply foresightedness
  9. hurried, irregular, pounding, or racing heartbeat or thrumming
  10. theory of invariable signal of self or surroundings
  11. halos surrounding lights
  12. headache, oppressive and throbbing
  13. increased sweating
  14. detriment of inclination
  15. loss of consciousness
  16. nausea
  17. night blindness
  18. overbright form of lights
  19. paralysis
  20. sensation of spinning
  21. slow heartbeat
  22. tunnel wraith
  23. vomiting

Other side effects not listed may also chance in some patients. If you notice any other effects, check into with your healthcare professional.